Optimal power-heat-carbon scheduling strategy for interconnected heterogeneous multi-microgrid considering hydrogen fuel cell vehicles.

The scale of multi-microgrid (MMG) and hydrogen fuel cell vehicles (HFCVs) is increasing dramatically with the increase in the new energy penetration ratio, and developing an integrated energy system containing a multi-microgrid for hydrogen fuel vehicles brings great challenges to power grid operation. Focusing on the difficulties of the access of multiple microgrids for the low-carbon and economic operation of the system, this paper proposes an optimal interconnected heterogeneous multi-microgrid power-heat-carbon scheduling strategy for hydrogen-fueled vehicles. Firstly, an HFCV model is established, and then an optimal scheduling model is constructed for the cooperative trading of power-heat-carbon in a multi-microgrid, on the basis of which the low-carbon economic operation of the multi-microgrid is realized. The results of the case study show that the scheduling strategy in this paper reduces carbon emissions by about 7.12% and costs by about 3.41% compared with the independent operation of the multi-microgrid. The degrees of interaction of each multi-microgrid are also analyzed under different HFCV penetration rates.

The combination use of inclisiran and statins versus statins alone in the treatment of dyslipidemia in mainland China: a cost-effectiveness analysis.

Objective: Statin is well-established as a classical lipid-lowering drug, and its cost has reduced considerably in the past years. Inclisiran is a new and effective lipid-lowering drug given as a subcutaneous injection at 6-month intervals. This study aims to evaluate the cost-effectiveness of the combination use of inclisiran and statin versus statin alone for dyslipidemia in the mainland China population. Methods: The Markov decision-making model was used, and the clinical data and real-world data were collected at the University of Hong Kong-Shenzhen Hospital (HKU-SZH). Patients with cardiovascular disease (CVD) and blood lipid levels above the target on statin therapy were included as the target population and analyzed for cardiovascular events, future medical expenses, and the calculation made for the total life cost, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs). Sensitivity analysis was conducted to evaluate the influence of parameter uncertainty on the base-case analysis results. Results: If inclisiran was priced at Chinese renminbi (RMB) 20,000.00 (USD 2,973.49) per injection, patients in the inclisiran and statin group would incur an incremental cost of RMB 449,233.56 (USD 66,789.60) compared with the statin group, and they would obtain 0.21 more QALYs in their life cycle. The subsequent ICER of RMB 2,127,756.78 (USD 316,343.32)/QALY was significantly higher than the willingness-to-pay (WTP) threshold of 3 times the per capita GDP of China, which was RMB 257,094.00 (USD 38,223.33)/QALY, suggesting that the combined use of inclisiran and statin was not cost-effective. If the price of inclisiran were reduced to RMB 2,500.00 (USD 371.69)/injection, the ICER of patients in the inclisiran and statin group would become RMB 257,790.63 (USD 38,326.91)/QALY, which is slightly lower than the WTP threshold of 3 times the per capita GDP of China, indicating that the combined use of inclisiran and statin would be cost-effective. Conclusion: If inclisiran is priced at RMB 20,000.00 (USD 2,973.49)/injection, then the combined use of inclisiran and statins is not cost-effective compared with statin alone. It will be economical only if the price of inclisiran is reduced by more than 88%.

Health risk assessment and development of human health ambient water quality criteria for PCBs in Taihu Basin, China.

Polychlorinated biphenyls (PCBs) are a class of typical persistent organic pollutants (POPs) with carcinogenicity and extensively found in diverse environmental mediums. The Taihu Basin is one of the most economically developed regions in China, and it has also caused a lot of historical legacy and unconscious emissions of PCBs, posing a threat to the health of people in the region. This study counted the concentrations of PCBs in five environmental media (water, soil, air, dust, and food) in the Taihu Basin from 2000 to 2020 and used Monte Carlo simulation to simulate the multi-channel exposure of PCBs in people of different ages (children, teenagers, and adults), and evaluated their noncarcinogenic and carcinogenic health risks. Finally, the human health ambient water quality standards (AWQC) for PCBs were obtained using regional exposure parameters and bioaccumulation factors. The results showed that the pollution of PCBs in the Taihu Basin was relatively serious in China. The concentration of PCBs in dust is higher than other environmental media. And exposure to water and food is the main exposure pathway for PCBs in the population of the region. Besides, PCBs pose no noncarcinogenic risk to people in this region, but their carcinogenic risk to residents exceeds the safety threshold. Among the three population groups, adults have the highest risk of cancer, and prevention measures need to be taken by controlling the intake of related foods and the concentration of PCBs in water. The following human health AWQC values of the PCBs in Taihu Basin is 3.2 × 10-9 mg/L.

Quality assessment and Q-markers discovery in Citri Sarcodactylis Fructus by integrating serum pharmacochemistry and network pharmacology.

INTRODUCTION: Citri Sarcodactylis Fructus (CSF), a common fruit and traditional Chinese medicine (TCM), has been hindered in its further development and research owing to the lack of comprehensive and specific quality evaluation standards. OBJECTIVE: This study aimed to establish clear TCM quality standards related to the therapeutic mechanisms of CSF and to provide a basis for subsequent research and development. METHODS: Ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap high-resolution mass spectrometry (UPLC-Q-orbitrap HRMS) technology was used to comprehensively identify CSF components and explore their absorbance levels in rat serum. Network pharmacology research methods were employed to investigate the potential mechanisms of action of the identified components in the treatment of major clinical diseases. Subsequently, a combination of HPLC chromatographic fingerprinting for qualitative analysis and multi-index content determination was used to evaluate the detectability of the identified quality markers (Q-markers). RESULTS: Twenty-six prototype components were tentatively characterized in rat serum. Network pharmacology analysis showed six effective components, namely 7-hydroxycoumarin, isoscopoletin, diosmin, hesperidin, 5,7-dimethoxycoumarin, and bergapten, which played important roles in the treatment of chronic gastritis, functional dyspepsia, peptic ulcer, and depression and were preliminarily identified as Q-markers. The results of content determination in 15 batches of CSF indicated significant differences in the content of medicinal materials from different origins. However, compared with the preliminarily determined Q-markers, all six components could be measured and were determined as Q-markers of CSF. CONCLUSION: The chemical Q-markers obtained in this study could be used for effective quality control of CSF.

Psychometric Properties of the Chinese Version of the ElectroConvulsive Therapy Cognitive Assessment: An Electroconvulsive Therapy-Specific Cognitive Screening Tool.

OBJECTIVES: Electroconvulsive therapy (ECT) is an effective somatic treatment, but it may be limited by cognitive adverse effects. The existing cognitive screening instruments often lack specificity to ECT-associated cognitive deficits. The ElectroConvulsive Therapy Cognitive Assessment was developed and validated in a clinical setting, but the reliability and validity of the Chinese version of ElectroConvulsive Therapy Cognitive Assessment (ECCA-C) have not been studied in a large clinical sample. METHODS: The ECCA-C and the Montreal Cognitive Assessment (MoCA) were administered to patients with major depressive disorder (MDD) undergoing ECT at 3 time points: pretreatment (baseline), before the fifth treatment, and 1 week posttreatment. The instruments were also administered to a sample of healthy subjects. RESULTS: Sixty-five patients with MDD and 50 age- and sex-matched healthy controls were recruited in this study. Overall, the patient group had statistically significantly lower MoCA and ECCA-C scores than the control group (both P values <0.001). The Cronbach α of the ECCA-C was 0.88 at baseline. Statistically significant decreases over time were observed in ECCA-C: pre-ECT (23.9 ± 4.0) > mid-ECT (21.3 ± 3.4) > post-ECT (18.7 ± 4.8) (all P values <0.001), whereas no statistically significant changes in MoCA scores were found at these 3 time points (F = 1.86, P = 0.165). A cutoff score of 26.5 on the ECCA-C was found to best differentiate between MDD patients and healthy controls. CONCLUSIONS: The ECCA-C showed satisfactory psychometric properties and may be a more sensitive instrument than the MoCA to assess cognitive impairment associated with ECT.

[Analysis on Change in Soil Organic Carbon Content of Farmland in Yangtze River Economic Belt Under Different Fertilizing Measures].

The literature from a long-term fertilization experiment in the Yangtze River Economic Belt from January 1992 to May 2022 was collected, and the data of farmland soil organic carbon were extracted and integrated. Using the normalization treatment and the analysis method of relative annual variation, the overall change in soil organic carbon content in farmland in the Yangtze River Economic Belt under different long-term fertilization measures was studied, and the change differences of soil organic carbon content under three tillage modes were compared so as to judge and analyze the influence of the duration of the experiment on soil organic carbon dynamics. The results showed that under different long-term fertilization measures, the organic carbon content of farmland soil in the Yangtze River Economic Belt in China showed an overall upward trend. The NP, NPK, O, and NPKO treatments all increased the organic carbon content of agricultural soils, with that of the NPKO treatment being the largest. The sole application of inorganic nitrogen fertilizer reduced the organic carbon content of the soil. The rates of change in soil organic carbon content were 0.22 g·(kg·a)-1, 0.24 g·(kg·a)-1, and 0.16 g·(kg·a)-1for dryland, paddy, and water-dry rotation farmland, respectively. Additionally, the relatively rapid increase effect of organic carbon brought by the O and NPKO treatments could last for no more than 28 years in dryland soil but could still last for more than 28 years in paddy field and paddy-upland rotation soil. There was some variation in the rate of change of soil organic carbon content between soil types. The average rate of change of organic carbon was 0.25 g·(kg·a)-1for red soils, 0.14 g·(kg·a)-1 for brown soils, 0.19 g·(kg·a)-1 for tidal soils, and 0.15 g·(kg·a)-1 for rice soils. The trend of NPKO>O>NPK>NPK>NP>N was basically maintained for the rate of change in soil organic carbon content. The NPKO treatments were all significantly higher than the chemical fertilizer (N, NP, and NPK) treatments alone. The N treatment showed a reduction in organic carbon content in both red soil and rice soils. Considering the carbon fixation of farmland soil, the combined application of organic and inorganic fertilizers is a more suitable fertilization method in this area.

Multi-class organic pollutants in PM2.5 in mixed area of Shanghai: Levels, sources and health risk assessment.

The occurrence of 25 multi-class pollutants comprising phthalate esters (PAEs), polycyclic aromatic hydrocarbons (PAHs), and synthetic musks (SMs) were studied in PM2.5 samples collected at an industrial/commercial/residential/traffic mixed area in Shanghai during four seasons. During the whole period, a slight exceedance of the PM2.5 annual limit was observed, with an average of 36.8 µg/m3, and PAEs were the most predominant, accounting for >70 % of the studied organic pollutants in PM2.5, followed by PAHs and SMs. Statistically significant differences were observed for the concentrations of PM2.5, PAEs, PAHs, and SMs in winter and summer. This seasonal variation could be derived from anthropogenic activities and atmospheric dynamics. Principal component analysis (PCA) and PAHs ratios suggested a mixed source mainly derived from vehicle emissions and industrial processes. Moreover, gaseous pollutants were also accounted for, indicating the emission of PAHs might accompany the NO2 emission process. Finally, inhalation of PM2.5-bound organic pollutants for carcinogenic and non-carcinogenic risks were estimated as average values for each season, showing outside the safe levels in autumn and winter in some cases, suggesting that new policies should be to developed to reduce their emissions and protect human health in this area.

Freshwater environment risk assessment and derivation of human health ambient water quality criteria for SCCPs in China.

Short-chain chlorinated paraffins (SCCPs, CxH2x+2-yCly, where x = 10 to 13 and y = 3 to x) are a complex family of emerging contaminants that have been identified as persistent, bioaccumulative and toxic (PBT) substances. Because of their persistence, high toxicity, bioaccumulation and long-distance mobility, SCCPs were added to the list of controlled POPs in the Stockholm Convention in 2017. China is the largest producer and user of SCCPs all over the world, thus SCCPs have been widely distributed in the freshwater environment. But the ecological risk and human health risk of SCCPs in China were still less evaluated. This study collected and screened the exposure data of SCCPs in freshwater environment in China, and then evaluated the freshwater and sediments ecological risk of SCCPs by risk quotient (RQ) method and the human health risk by margin of exposure (MOE) method. Our results showed that the pollution of SCCPs in the freshwater environment in China was not optimistic. The ecological risks and human health risks had occurred, and even there were high ecological risks occurred in some regions in China. Besides, because of the absence of the concentration threshold of SCCPs to protect human health in freshwater at present, we derived the human health ambient water quality criteria (AWQC) values of SCCPs based on exposure data and bioaccumulation factor (BAF) in China. The human health AWQC values of SCCPs ranged from 14.99 ng L-1 to 154.54 ng L-1 in different regions in China, and the national human health AWQC value was determined as 24.08 ng L-1. This study will provide the scientific references for the management and control of SCCPs in China, especially for the formulation of standard of water environmental quality for SCCPs.

Ecological risk assessment of aquatic organisms induced by heavy metals in the estuarine waters of the Pearl River.

With the rapid economic development of China's coastal areas and the growth of industry and population, the problem of heavy metal contamination in estuarine waters is increasing in sensitivity and seriousness. In order to accurately and quantitatively describe the current status of heavy metal contamination and identify sensitive aquatic organisms with high ecological risks, five heavy metals in eight estuaries of the Pearl River were monitored at monthly intervals from January to December in 2020, and the ecological risks of aquatic organisms induced by heavy metals were evaluated using Risk quotients (RQ) and species sensitivity distributions (SSD) methods. The results showed that the concentrations of As, Cu, Pb, Hg and Zn in estuaries of the Pearl River were (0.65-9.25) µg/L, (0.07-11.57) µg/L, (0.05-9.09) µg/L, (< 0.40) µg/L and (0.67-86.12) µg/L, respectively. With the exception of Hg in Jiaomen water, the other heavy metals in each sampling site met or exceed the water quality standard of Grade II. The aquatic ecological risks of As, Pb and Hg were generally low in the waters of the Pearl River estuary, but individual aquatic organisms are subject to elevated ecological risks due to Cu and Zn. The content of Zn has a lethal effect on the crustaceans Temora Stylifera, and the content of Cu has a serious impact on the mollusks Corbicula Fluminea and has a certain impact on the crustaceans Corophium sp. and the fish Sparus aurata. Heavy metal levels and joint ecological risks (msPAF) in the Humen, Jiaomen, Hongqimen, and Hengmen estuaries were slightly higher than in other estuaries, and the Yamen estuary had the lowest contration of heavy metals and ecological risk. Research findings can serve as a basis for formulating water quality standards for heavy metals and for protecting aquatic biodiversity in the Pearl River Estuary.

Acute Toxicity Assessment and Prediction Models of Four Heavy Metals.

Water quality criteria (WQC) are developed to protect aquatic organisms. Toxicity data of local fish are essential to improve the applicability of WQC derivatives. However, the paucity of local cold-water fish toxicity data limits the development of WQC in China. Brachymystax lenok is a representative Chinese-endemic cold-water fish, which plays an important role in the characterization of metal toxicity in the water environment. Whereas, the ecotoxicological effects of copper, zinc, lead and cadmium, as well as its potential as a test species for the metal WQC, remain to be investigated. In our study, acute toxicity tests of copper, zinc, lead and cadmium were performed on this fish according to the OECD method and 96 h-LC50 values were calculated. The results showed that the 96 h-LC50 values of Cu2+, Zn2+, Pb2+ and Cd2+ for B. lenok were 134, 222, 514 and 734 µg/L, respectively. Toxicity data for freshwater species and Chinese-native species were collected and screened, and the mean acute values of each metal for each species were ranked. The results showed that the accumulation probability of zinc by B. lenok was the lowest and less than 15%. Thus, B. lenok was sensitive to Zn and can be considered as the test cold-water fish for derivation of Zn WQC. In addition, B. lenok in comparison with warm-water fish, we found that cold-water fish are not always more sensitive to heavy metals than warm-water fish. Finally, the models for toxic effects prediction of different heavy metals on the same species were constructed and evaluated the reliability of the model. We suggest that the alternative toxicity data provided by the simulations can be used to derive WQC for metals.

Vaccine inequity-induced COVID-19 dilemma: Time to sober up.

UNSTRUCTURED: The ongoing coronavirus disease 2019 pandemic has not only posed a serious threat to public health but has also imposed a heavy burden on medical systems and global economies. To combat this challenge, unprecedented efforts have been made by governments and the scientific community in the development and production of vaccines. As a result, less than a year elapsed between identification of a novel pathogen sequence and large-scale vaccine rollout. However, much of the focus and debate has increasingly shifted to the looming risk of global vaccine inequity and whether we could do more to modify this risk. In this paper, we first outline the scope of inequitable vaccine distribution and identify its truly catastrophic consequences. Then, from the perspectives of political will, free markets and profit-driven enterprises based on patent and intellectual property protection, we analyze in-depth the root causes why this phenomenon is so difficult to combat. Apart from these, some specific and crucial solutions that should be undertaken in the long term were also put forward, in order to provide a useful reference for the authorities, stakeholders and researchers involved in addressing this global crisis and the next one.

The initiation, exploration, and development of hospital-based health technology assessment in China: 2005 ‒ 2022.

A hospital-based health technology assessment (HB-HTA) can provide the evidence needed to inform clinical decisions at the administrative level. With the implementation of a new round of medical and health care system reforms in China, such as the abolition of medical mark-ups, adoption of modern hospital management systems, reform of diagnosis related groups (DRGs) payment, and performance evaluations for public hospitals, medical institutions increasingly need HB-HTA. The development of HB-HTA in China can be divided into three phases: An initiation phase (2005-2014), a preliminary exploratory phase (2015-2017), and a rapid development phase (2018-present). HB-HTA has been used to manage medical consumables, medical devices, and medicines, but there are still problems and challenges in terms of concept recognition, the mode of development, and limited professionals and data. To promote and use HB-HTA in developing countries, we have identifies the development paths and recommendations for implementation based on a case study in China, which can be summarized as follows: enhancing the top-level design of HB-HTA, formulating HB-HTA guidelines, further promoting the main ideas of HB-HTA, concentrating on the training of evaluation personnel, establishing an HB-HTA network and paying attention to the flexibility of HB-HTA in the application process, and multi- stakeholder participation.

Risk Assessment of Phthalate Esters in Baiyangdian Lake and Typical Rivers in China.

Phthalate esters (PAEs) are frequently tracked in water environments worldwide. As a typical class of endocrine disruptor chemicals (EDCs), PAEs posed adverse effects on aquatic organisms at low concentration. Thus, they have attracted wide attention in recent years. In the present study, the concentrations of seven typical PAEs from 30 sampling sites in Baiyangdian Lake were measured, and the environmental exposure data of PAEs were gathered in typical rivers in China. Then, based on the aquatic life criteria (ALCs) derived from the reproductive toxicity data of aquatic organisms, two risk assessment methods, including hazard quotient (HQ) and probabilistic ecological risk assessment (PERA), were adopted to evaluate the ecological risks of PAEs in water. The sediment quality criteria (SQCs) of DEHP, DBP, BBP, DIBP and DEP were deduced based on the equilibrium partitioning method. Combined with the gathered environmental exposure data of seven PAEs in sediments from typical rivers in China, the ecological risk assessments of five PAEs in sediment were conducted only by the HQ method. The results of ecological risk assessment showed that in terms of water, DBP and DIBP posed low risk, while the risk of DEHP in Baiyangdian Lake cannot be ignored and should receive attention. In typical rivers in China, BBP and DEP posed no risk, while DIBP and DBP posed potential risk. Meanwhile, DEHP posed a high ecological risk. As far as sediment is concerned, DBP posed a high risk in some typical rivers in China, and the other rivers had medium risk. DEHP posed a high risk only in a few rivers and low to medium risk in others. This study provides an important reference for the protection of aquatic organisms and the risk management of PAEs in China.

Study on the Impact of Collaborative Agglomeration of Manufacturing and Producer Services on PM2.5 Pollution: Evidence from Urban Agglomerations in the Middle Reaches of the Yangtze River in China.

In this paper, using panel data of 28 cities in the middle reaches of the Yangtze River from 2003 to 2020 as the research sample, we built a dynamic spatial Durbin model based on the STIRPAT (stochastic impacts by regression on population, affluence, and technology) model and conducted an empirical study on the impact of the coordinated agglomeration of manufacturing and producer services on particulate matter (PM) 2.5 pollution. The results show a significant positive spatial spillover effect of PM2.5 pollution in the middle reaches of the Yangtze River. The coordinated agglomeration of manufacturing and producer services in the urban agglomerations there is conducive to reducing PM2.5 pollution. Similar to the inverted-U curve of the classic environmental Kuznets curve hypothesis, there is a significant inverted-U curve relationship between PM2.5 pollution and economic growth in urban agglomerations in the middle reaches of the Yangtze River. The proportion of coal consumption, the proportion of secondary industry, and the urbanization level are significantly and positively correlated with PM2.5 pollution in urban agglomerations in this area. Technological innovation, environmental regulation, and annual average humidity play an important role in addressing the PM2.5 pollution and spatial spillover effect. Industrial structure and technological innovation are the main ways for the coordinated agglomeration of manufacturing and producer services to affect PM2.5. The research conclusion can be of great practical significance to optimize the regional industrial layout, control PM2.5 pollution, and establish a sustainable development policy system in the middle reaches of the Yangtze River in China.

Vehicle emissions of primary air pollutants from 2009 to 2019 and projection for the 14th Five-Year Plan period in Beijing, China.

Over the past decade, the emission standards and fuel standards in Beijing have been upgraded twice, and the vehicle structure has been improved by accelerating the elimination of 2.95 million old vehicles. Through the formulation and implementation of these policies, the emissions of carbon monoxide (CO), volatile organic compounds (VOCs), nitrogen oxides (NOx), and fine particulate matter (PM2.5) in 2019 were 147.9, 25.3, 43.4, and 0.91 kton in Beijing, respectively. The emission factor method was adopted to better understand the emissions characteristics of primary air pollutants from combustion engine vehicles and to improve pollution control. In combination with the air quality improvement goals and the status of social and economic development during the 14th Five-Year Plan period in Beijing, different vehicle pollution control scenarios were established, and emissions reductions were projected. The results show that the emissions of four air pollutants (CO, VOCs, NOx, and PM2.5) from vehicles in Beijing decreased by an average of 68% in 2019, compared to their levels in 2009. The contribution of NOx emissions from diesel vehicles increased from 35% in 2009 to 56% in 2019, which indicated that clean and energy-saving diesel vehicle fleets should be further improved. Electric vehicle adoption could be an important measure to reduce pollutant emissions. With the further upgrading of vehicle structure and the adoption of electric vehicles, it is expected that the total emissions of the four vehicle pollutants can be reduced by 20%-41% by the end of the 14th Five-Year Plan period.

Cultural Heritage Resource Development and Industrial Transformation Resource Value Assessment Based on BP Neural Network.

Mining and utilizing cultural heritage resources and creating and developing creative and cultural industries have become the priority direction of economic development, setting off a wave of cultural heritage resource development, and industrial transformation. Which cultural heritage resources can have the high value of industrial transformation has become one of the research topics that have attracted much attention. In view of this problem, research is of great significance to the development of cultural heritage resources and the field of industrial transformation. With the in-depth research on resource development and industrial transformation, the research on artificial neural network (ANN) in cultural industry transformation is gradually carried out, and its performance advantages are of great significance to solve the problem of value evaluation. This paper aims to study the application of the value assessment method based on the BP neural network (BPNN) in the development of cultural heritage resources and industrial transformation. Through the analysis and research of BPNN and cultural heritage resource development and industrial transformation, it can be applied to the construction of resource value assessment methods to solve the problem of improving the value level of cultural heritage resource development and industry. This paper analyzes BPNN, cultural heritage, and value evaluation methods, conducts experimental analysis on the performance of the algorithm, and uses related theoretical formulas to explain. The results show that the evaluation method has passed the random consistency test, and the results are valid. The obtained index popularity weight value is 0.134, the economic benefit weight value is 0.093, and the resource correlation degree weight value is 0.074, which can be used as the key criteria for resource value evaluation. The classification of resources through resource value assessment can provide theoretical support for the development and industrialization of cultural heritage and can meet the needs of improving the value and quality of cultural heritage development and industrial transformation, and the development level and satisfaction have been greatly improved.

Research on freshwater water quality criteria, sediment quality criteria and ecological risk assessment of triclosan in China.

Triclosan (TCS) is a broad-spectrum antimicrobial agent commonly used in pharmaceuticals and personal care products (PPCPs). The widespread use of TCS makes it frequently detected in various environmental mediums. In view of the high detection frequency of TCS in the aquatic environment and sediments, and its toxic effects on aquatic species, it is critical and necessary to derive Chinese TCS water quality criteria (WQC) and sediment quality criteria (SQC) for protecting Chinese aquatic organisms, and perform the ecological risk assessment. In fact, former research had derived the WQC of TCS mainly based on acute and chronic toxicity data. As an endocrine disrupting chemical (EDC), TCS poses adverse effects on the growth, development and reproduction of aquatic organisms at much lower concentration. Considering nonlethal endpoints are sensitive endpoints for EDCs, TCS long-term water quality criteria (LWQC) was derived based on reproduction and growth related endpoints. In this work, the acute toxicity data of 19 aquatic organisms and the chronic toxicity data of 15 aquatic organisms were obtained through collection and screening. The best fitting model of species sensitivity distribution (SSD) models including Normal, Log-Normal, Logistic and Log-Logistic of toxicity data was selected to derive WQC. The short-term and long-term WQC of TCS for Chinese aquatic organisms were 6.22 µg/L and 0.25 µg/L, respectively. Furthermore, through the phase-equilibrium partitioning method, SQC was derived based on WQC. SQC-low (SQC-L) and SQC-high (SQCH) were 0.13 mg/kg and 3.26 mg/kg, respectively. Moreover, the exposure concentration (EPC) data of TCS in Chinese rivers and sediments were collected. And through the hazard quotient (HQ) method and the joint probability curve (JPC) method we found that there were certain TCS ecological risks in Chinese rivers and sediments. Our work will provide a valuable reference for protecting aquatic organisms and minimizing TCS ecological risk in China.

Energy consumption and pollutant emission of diesel-fired combustion from 2009 to 2018 in Beijing, China.

Diesel-fired combustion is one of the main sources of air pollution in the world. In this study, to better understand the energy consumption and main air pollutant emissions of diesel-fired combustion, a practical investigation and historical data analyses were conducted to determine the variations and driving forces of diesel consumption, the distribution of diesel consumption, and the contribution of emissions among various industries. Based on the results of this study, future control measures can be proposed for diesel-fired combustion. The results show that economic development led to an increase in the total volume of passengers and freight transportation, and the number of diesel vehicles increased from 0.16 million in 2009 to 0.25 million in 2018. However, diesel consumption in Beijing decreased from 2.4 Mt in 2009 to 1.8 Mt in 2018 due to the dominant driving forces, such as structural optimization of the diesel vehicle fleet and stricter limit standards for single-vehicle fuel consumption. The use of diesel vehicles in the logistics and transportation industries and the use of diesel-fired machinery in the construction industry were the two main sources of diesel consumption, accounting for 55% and 23% of the total, respectively. The main air pollutant emissions from diesel-fired combustion from 2009 to 2018 first increased and then decreased, while the NOX emissions peaked at 74,800 tons in 2014, which was affected by the structural optimization of the vehicle fleet and the elimination of old diesel trucks. The emissions finally decreased to 54,000 tons in 2018, which was approximately 89% of the amount in 2009. However, the continuously increasing contribution of diesel combustion to the total emissions requires more attention. The electrification of diesel vehicles and the structural upgrading of diesel vehicles have played important roles in mitigating the emissions of diesel combustion. Our study suggests that consumption control targets should be set, reduction plans for key industries such as the logistics and transportation, construction, and tourism industries should be developed, and low-emission zones should be created to promote the elimination and updating of low-emission diesel vehicles and machinery.

Adverse effects in Daphnia magna exposed to e-waste leachate: Assessment based on life trait changes and responses of detoxification-related genes.

The sharp increase in e-waste derived from great consumption of electronic products has become a potential global environmental challenge. Limited information is available about the potential detrimental impact of e-waste on aquatic organisms. The present study investigated the expression of detoxification-related genes and life-history parameter changes in Daphnia magna exposed to e-waste leachate, simultaneously integrating with the chemical analysis of typical pollutants from e-waste leachate. The study aims at assessing impacts of e-waste to aquatic invertebrates and providing insights into its toxic mechanisms. The results showed high concentration of heavy metals like Cu (1657.14 ± 259.3 µg g-1, DW) and persistent organic compounds like polybrominated diphenyl ethers (7831.32 ± 1273.86 ng g-1, DW) in stream sediments near e-waste dismantling areas. Chronic exposure to these pollutants can affect the growth and reproduction of D. magna, resulting in significant development retardation, decreased total egg production per female, and even smaller body size. Expression of some detoxification and reproduction-related genes including DappuHR96, CYP360a, P-gp, EcR, CYP314 and Vtg exhibited different response patterns depending on the e-waste leachate concentration. E-waste leachate may affect the expression of detoxification-related and growth and reproduction-related genes and disrupt the growth and reproduction processes of D. magna.

Quantification and valuation of ecosystem services in life cycle assessment: Application of the cascade framework to rice farming systems.

The integration of ecosystem service (ES) assessment with life cycle assessment (LCA) is important for developing decision support tools for environmental sustainability. A prequel study has proposed a 4-step methodology that integrates the ES cascade framework within the cause-effect chain of life cycle impact assessment (LCIA) to characterize the physical and monetary impacts on ES provisioning due to human interventions. We here follow the suggested steps in the abovementioned study, to demonstrate the first application of the integrated ES-LCIA methodology and the added value for LCA studies, using a case study of rice farming in the United States, China, and India. Four ES are considered, namely carbon sequestration, water provisioning, air quality regulation, and water quality regulation. The analysis found a net negative impact for rice farming systems in all three rice producing countries, meaning the detrimental impacts of rice farming on ES being greater than the induced benefits on ES. Compared to the price of rice sold in the market, the negative impacts represent around 2%, 6%, and 4% of the cost of 1 kg of rice from China, India, and the United States, respectively. From this case study, research gaps were identified in order to develop a fully operationalized ES-LCIA integration. With such a framework and guidance in place, practitioners can more comprehensively assess the impacts of life cycle activities on relevant ES provisioning, in both physical and monetary terms. This may in turn affect stakeholders' availability to receive such benefits from ecosystems in the long run.